Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 3/20 | 0.42 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 4/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | EIF4E | P06730 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | F10 | P00742 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264012 | 0.92 | IL2 (0.49) | IL2POLQCSF1RCYP11B2MAPK11 | |
| SCHEMBL8263042 | 0.91 | IL2 (0.40) | IL2CSF1RRORCTYK2JAK2 | |
| SCHEMBL8261524 | 0.88 | IL2 (0.42) | IL2POLQCSF1RCYP11B2RORC | |
| SCHEMBL8261521 | 0.83 | IL2 (0.41) | IL2POLQCSF1RCYP11B2RORC | |
| SCHEMBL8260146 | 0.83 | IL2 (0.39) | IL2POLQCSF1RCYP11B2NPC1 | |
| SCHEMBL8263046 | 0.82 | IL2 (0.48) | IL2RORC | |
| SCHEMBL8263036 | 0.80 | POLB (0.42) | IL2 | |
| SCHEMBL8262105 | 0.80 | IL2 (0.47) | IL2POLQCSF1RCYP11B2MAPK11 | |
| SCHEMBL8263029 | 0.79 | IL2 (0.44) | IL2POLQCSF1RCYP11B2TYK2 | |
| SCHEMBL8261520 | 0.79 | IL2 (0.38) | IL2CSF1RCYP11B2RORCF10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006081389-A1 | THIOPHENE COMPOUNDS FOR INFLAMMATION AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP. (US) | 2006-08-03 | — | — | WO | disclosed |