Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 11/20 | 0.70 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.61 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.53 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.53 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.51 |
| ▸ | CLK2 | P49760 | 3/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | CLK3 | P49761 | 1/20 | 0.51 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.51 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13680578 | 0.87 | GSK3B (0.70) | FGFR1TGFBR1DYRK1ACLK2CLK4 | |
| SCHEMBL13115655 | 0.84 | FGFR1 (0.71) | FGFR1FGFR2FGFR3KDM4EHTT | |
| SCHEMBL18042017 | 0.83 | TGFBR1 (0.69) | FGFR1FGFR2FGFR3KDM4EHTT | |
| SCHEMBL18041596 | 0.83 | FGFR1 (0.49) | FGFR1FGFR2FGFR3KDM4EHTT | |
| SCHEMBL15640161 | 0.83 | FGFR1 (0.51) | FGFR1FGFR2FGFR3KDM4EHTT | |
| SCHEMBL29677124 | 0.83 | FGFR1 (0.49) | FGFR1FGFR2FGFR3KDM4EHTT | |
| SCHEMBL2460902 | 0.82 | FGFR1 (1.00) | FGFR1FGFR2FGFR3KDM4EHTT | |
| SCHEMBL18041898 | 0.82 | FGFR1 (0.48) | FGFR1FGFR2FGFR3KDM4EHTT | |
| SCHEMBL18041819 | 0.81 | TGFBR1 (0.70) | FGFR1FGFR2FGFR3KDM4EHTT | |
| SCHEMBL29677020 | 0.81 | TGFBR1 (0.70) | FGFR1FGFR2FGFR3KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833816-B1 | SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |
| WO-2006069788-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2006-07-06 | — | — | WO | disclosed |