Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.70 |
| ▸ | CLK1 | P49759 | 2/20 | 0.70 |
| ▸ | CLK2 | P49760 | 2/20 | 0.70 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.70 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.70 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.70 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.70 |
| ▸ | CLK3 | P49761 | 1/20 | 0.70 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.70 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.70 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.70 |
| ▸ | TRPA1 | O75762 | 12/20 | 0.60 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.56 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.55 |
| ▸ | PIM1 | P11309 | 3/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8264120 | 0.87 | FGFR1 (0.70) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL27537145 | 0.86 | GSK3B (0.64) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL16573980 | 0.84 | GSK3B (0.71) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL16473226 | 0.84 | TRPA1 (0.54) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL15638586 | 0.83 | TGFBR1 (0.62) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL18041659 | 0.83 | MAPK14 (0.57) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL2455100 | 0.82 | GSK3B (1.00) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL18041743 | 0.82 | TGFBR1 (0.60) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL15639974 | 0.82 | TRPA1 (0.52) | GSK3BCLK1CLK2CDK5DYRK1A | |
| SCHEMBL29677032 | 0.82 | TGFBR1 (0.50) | GSK3BCLK1CLK2CDK5DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |
| US-7582658-B2 | Bicyclic compound | ASAHI KASEI PHARMA CORPORATION (JP) | 2009-09-01 | — | — | US | disclosed |