SCHEMBL8264124

SCHEMBL8264124

O/C=C(\O)c1ccc2c(c1)CN(Cc1ccccc1)C2

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 2/20 0.50
KCNH2 Q12809 1/20 0.50
SIGMAR1 Q99720 5/20 0.49
TMEM97 Q5BJF2 4/20 0.49
ADRA2A P08913 3/20 0.49
ADRA2B P18089 3/20 0.49
ADRA2C P18825 2/20 0.49
OPRK1 P41145 3/20 0.47
DRD4 P21917 2/20 0.47
HTR2B P41595 2/20 0.47
HTR1A P08908 1/20 0.47
SLC6A2 P23975 1/20 0.47
HTR2C P28335 1/20 0.47
SLC6A4 P31645 1/20 0.47
HTR5A P47898 1/20 0.47
SLC6A3 Q01959 1/20 0.47
OPRM1 P35372 3/20 0.46
CYP1A2 P05177 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
MEN1 O00255 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8122252 0.82 HDAC1 (0.55) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
Hydrochloric Acid SCHEMBL7040966 0.81 HDAC1 (0.54) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
Hydrochloric Acid SCHEMBL7041877 0.81 HDAC1 (0.54) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
Hydrochloric Acid SCHEMBL7041875 0.79 HDAC1 (0.53) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
SCHEMBL7041614 0.79 OPRM1 (0.64) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
SCHEMBL30073105 0.77 SIGMAR1 (0.60) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
SCHEMBL3692387 0.76 ESR1 (0.58) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
SCHEMBL1205833 0.76 ACACB (0.55) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
SCHEMBL1206388 0.75 SIGMAR1 (0.54) HDAC1KCNH2SIGMAR1TMEM97ADRA2A
SCHEMBL31514906 0.75 SIGMAR1 (0.54) HDAC1KCNH2SIGMAR1TMEM97ADRA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1848694-B1 HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 HOFFMANN LA ROCHE (CH) 2009-11-25 EP disclosed
WO-2006082001-A1 HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 F.HOFFMANN-LA ROCHE AG (CH) 2006-08-10 WO disclosed