Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 9/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 4/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.31 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25147461 | 0.77 | RPS6KA3 (0.38) | OPRL1MAOARPS6KA3PDE2A | |
| SCHEMBL22502738 | 0.77 | OPRL1 (0.45) | OPRL1MAOARPS6KA3PDE2APDE1A | |
| SCHEMBL22156301 | 0.71 | PDE1A (0.41) | OPRL1PDE2APDE1APDE1BPDE1C | |
| SCHEMBL24962101 | 0.71 | NUDT1 (0.42) | — | |
| SCHEMBL19918909 | 0.71 | JAK2 (0.34) | SCN9A | |
| SCHEMBL23279553 | 0.71 | OPRL1 (0.43) | OPRL1MAOARPS6KA3PDE2A | |
| SCHEMBL19088439 | 0.70 | OPRL1 (0.45) | OPRL1MAOARPS6KA3PDE2A | |
| SCHEMBL25926930 | 0.70 | MAPK1 (0.42) | OPRL1MAOADAO | |
| SCHEMBL24497568 | 0.69 | JAK2 (0.35) | SCN9A | |
| SCHEMBL10247692 | 0.69 | NPSR1 (0.37) | OPRL1MAOARPS6KA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006082001-A1 | HETEROCYCLIC SUBSTITUTED PHENYL METHANONES AS INHIBITORS OF THE GLYCINE TRANSPORTER 1 | F.HOFFMANN-LA ROCHE AG (CH) | 2006-08-10 | — | — | WO | disclosed |