Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.51 |
| ▸ | AR | P10275 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.44 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.44 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1674044 | 1.00 | GPR119 (0.51) | GPR119ARNR1H2NR1H3ABHD6 | |
| SCHEMBL21001077 | 0.85 | GPR119 (0.52) | GPR119ARNR1H2NR1H3EGLN2 | |
| SCHEMBL22772313 | 0.85 | NR1H2 (0.47) | GPR119NR1H2NR1H3ABHD6ROCK2 | |
| SCHEMBL83391 | 0.84 | MEN1 (0.53) | NR1H2NR1H3ABHD6ROCK2EIF4A3 | |
| SCHEMBL82171 | 0.84 | NR1H2 (0.59) | NR1H2NR1H3ABHD6ROCK2 | |
| SCHEMBL521801 | 0.84 | NR1H2 (0.49) | GPR119NR1H2NR1H3ABHD6ROCK2 | |
| SCHEMBL1673567 | 0.84 | NR1H2 (0.59) | NR1H2NR1H3ABHD6ROCK2 | |
| SCHEMBL1673737 | 0.84 | MEN1 (0.53) | NR1H2NR1H3ABHD6ROCK2EIF4A3 | |
| SCHEMBL83834 | 0.84 | NR1H2 (0.59) | NR1H2NR1H3ABHD6ROCK2 | |
| SCHEMBL31421008 | 0.84 | GPR119 (0.51) | GPR119ARALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1805164-B9 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-09-07 | — | — | EP | disclosed |
| EP-1805164-B1 | 6-(PYRIDINYL)-4-PYRIMIDONE DERIVATES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI TANABE PHARMA CORP (JP) | 2011-02-23 | — | — | EP | disclosed |