Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 18/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 16/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.31 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL825976 | 0.80 | CHEK2 (0.36) | CHEK2 | |
| SCHEMBL4413005 | 0.79 | TLR8 (0.46) | TLR7TLR8 | |
| SCHEMBL823774 | 0.71 | MKNK1 (0.43) | TLR7TLR8 | |
| SCHEMBL4413009 | 0.69 | MAP4K4 (0.43) | TLR7TLR8 | |
| SCHEMBL823722 | 0.68 | NPC1 (0.46) | — | |
| SCHEMBL823715 | 0.67 | TLR8 (0.43) | TLR7TLR8 | |
| SCHEMBL823723 | 0.67 | NPC1 (0.41) | TLR7TLR8 | |
| SCHEMBL823619 | 0.67 | TLR8 (0.40) | TLR7TLR8 | |
| SCHEMBL823727 | 0.66 | TLR8 (0.39) | TLR7TLR8 | |
| SCHEMBL823602 | 0.66 | PRMT6 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143394-B2 | Pyrido(3,2-d)pyrimidines useful for treating viral infections | GILEAD SCIENCES, INC. (US) | 2012-03-27 | — | — | US | disclosed |