Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ATF1 | P18846 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8267708 | 0.81 | GPBAR1 (0.43) | TACR1CNR1CNR2POLBSMN1; SMN2 | |
| SCHEMBL11923165 | 0.80 | TACR1 (0.39) | TACR1CNR1CNR2POLBSMN1; SMN2 | |
| SCHEMBL8266130 | 0.79 | GPBAR1 (0.44) | TACR1CNR1CNR2POLBSMN1; SMN2 | |
| SCHEMBL11923190 | 0.77 | GPBAR1 (0.41) | TACR1CNR1CNR2POLBSMN1; SMN2 | |
| SCHEMBL11923246 | 0.77 | THRB (0.42) | TACR1CNR1CNR2POLBSMN1; SMN2 | |
| SCHEMBL8266014 | 0.76 | HSD17B10 (0.48) | TACR1CNR1CNR2POLBSMN1; SMN2 | |
| SCHEMBL8267731 | 0.75 | GPBAR1 (0.43) | TACR1CNR1CNR2GPBAR1 | |
| SCHEMBL11923235 | 0.75 | ALDH1A1 (0.40) | TACR1CNR1CNR2POLBSMN1; SMN2 | |
| SCHEMBL11923293 | 0.74 | JAK1 (0.42) | TACR1CNR1CNR2POLBSMN1; SMN2 | |
| SCHEMBL8946719 | 0.72 | ALDH1A1 (0.53) | CNR1CNR2POLBSMN1; SMN2PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006050476-A2 | PYRIMIDINE DERIVATIVES AS ION CHANNEL MODULATORS AND METHODS OF USE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2006-05-11 | — | — | WO | disclosed |