Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NHERF1 | O14745 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | THRB | P10828 | 2/20 | 0.60 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | DHODH | Q02127 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 2/20 | 0.56 |
| ▸ | CA2 | P00918 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | CA7 | P43166 | 1/20 | 0.56 |
| ▸ | CA9 | Q16790 | 1/20 | 0.56 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12124929 | 0.91 | RAB9A (0.69) | RAB9AMEN1KMT2ATHRBSLC2A1 | |
| SCHEMBL274513 | 0.89 | CA1 (0.68) | NHERF1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL2989285 | 0.88 | CA12 (0.66) | NHERF1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL1615670 | 0.88 | CA1 (0.66) | NHERF1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL9805589 | 0.86 | NHERF1 (0.62) | NHERF1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL9644563 | 0.86 | RAB9A (0.63) | RAB9AMEN1KMT2ATHRBSLC2A1 | |
| SCHEMBL9176722 | 0.85 | SMN1; SMN2 (0.72) | RAB9AMEN1KMT2ATHRBSLC2A1 | |
| SCHEMBL2270040 | 0.84 | CA12 (0.61) | NHERF1RAB9AMEN1KMT2AMAPT | |
| Boric Acid SCHEMBL28174370 | 0.84 | CA12 (0.61) | NHERF1RAB9AMEN1KMT2AMAPT | |
| SCHEMBL6705884 | 0.84 | CA12 (0.61) | NHERF1RAB9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11691984-B2 | Compounds and methods for DCAF-mediated protein degradation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-07-04 | — | — | US | disclosed |
| US-11691984-B2 | Compounds and methods for DCAF-mediated protein degradation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-07-04 | — | — | US | disclosed |
| EP-3864030-A1 | COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION | The Scripps Research Institute (US) | 2021-08-18 | — | — | EP | disclosed |
| US-20200190105-A1 | COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION | THE SCRIPPS RESEARCH INSTITUTE | 2020-06-18 | — | — | US | disclosed |
| WO-2006064286-A1 | CATHEPSIN S INHIBITORS | MEDIVIR UK LTD (GB) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200190105-A1 | COMPOUNDS AND METHODS FOR DCAF-MEDIATED PROTEIN DEGRADATION | DCAF1, CUL4A, DCAF15 | NHERF1 2731/4885RAB9A 2928/4885MEN1 3057/4885 |
| US-11691984-B2 | Compounds and methods for DCAF-mediated protein degradation | DCAF1, CUL4A, DCAF15 | NHERF1 2731/4885RAB9A 2928/4885MEN1 3057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.