Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPY1R | P25929 | 1/20 | 0.44 |
| ▸ | NPY2R | P49146 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.39 |
| ▸ | PPARG | P37231 | 4/20 | 0.37 |
| ▸ | PPARA | Q07869 | 3/20 | 0.36 |
| ▸ | PPARD | Q03181 | 2/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4891261 | 0.86 | MAPT (0.45) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL5631447 | 0.81 | LMNA (0.57) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL4882997 | 0.81 | LMNA (0.44) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL14227050 | 0.78 | MAPT (0.45) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL4890940 | 0.78 | MAPT (0.46) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL14198717 | 0.78 | MAPT (0.46) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL8348132 | 0.77 | LMNA (0.49) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL4881191 | 0.77 | ADRB1 (0.49) | MAPTLMNANPY1RNPY2RPDE4D | |
| SCHEMBL4888905 | 0.77 | PDE3B (0.52) | MAPTLMNANPY1RNPY2RPDE3B | |
| SCHEMBL4890674 | 0.77 | PDE3B (0.45) | MAPTLMNANPY1RNPY2RPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006060127-A2 | COMPOUNDS WITH MIXED PDE-INHIBITORY AND β-ADRENERGIC ANTAGONIST OR PARTIAL AGONIST ACTIVITY FOR TREATMENT OF HEART FAILURE | ARTESIAN THERAPEUTICS, INC. (US) | 2006-06-08 | — | — | WO | disclosed |