Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | METAP1 | P53582 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8268928 | 0.93 | ALDH1A1 (0.55) | KDM4EMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8268926 | 0.91 | KDM4E (0.51) | PDE10AKDM4EMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5794261 | 0.90 | ALDH1A1 (0.57) | PDE10AKDM4EMAPK1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10992611 | 0.87 | MAPT (0.57) | KDM4EMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8268364 | 0.83 | MAPT (0.77) | KDM4EMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8269894 | 0.83 | KMT2A (0.50) | PDE10AKDM4ESMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL10992499 | 0.81 | ALDH1A1 (0.59) | KDM4EMAPK1SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL8271004 | 0.81 | DHODH (0.61) | KDM4EALDH1A1RAB9ANPC1MAPT | |
| SCHEMBL899745 | 0.81 | KMT2A (0.74) | KDM4EALDH1A1MAPTTP53KMT2A | |
| SCHEMBL7506358 | 0.80 | CTSB (0.54) | KDM4EMAPK1SMN1; SMN2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006034512-A2 | PHENYL-SUBSTITUTED QUINOLINE AND QUINAZOLINE COMPOUNDS FOR THE TREATMENT OF DIABETES | BAYER PHARMACEUTICALS CORPORATION (US) | 2006-03-30 | — | — | WO | disclosed |