Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 3/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | WNT3 | P56703 | 2/20 | 0.35 |
| ▸ | SFRP1 | Q8N474 | 2/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | TGM2 | P21980 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8272248 | 0.90 | RECQL (0.48) | HSD17B10HPGDPREPRECQLTGM2 | |
| SCHEMBL7175857 | 0.85 | PREP (0.46) | HSD17B10PREPNR1H2 | |
| SCHEMBL2708283 | 0.85 | PREP (0.46) | HSD17B10PREPNR1H2 | |
| SCHEMBL2710052 | 0.85 | PREP (0.46) | HSD17B10PREPNR1H2 | |
| SCHEMBL7143154 | 0.83 | HSD17B10 (0.38) | HSD17B10NR1H2 | |
| SCHEMBL8990042 | 0.83 | HSD17B10 (0.38) | HSD17B10NR1H2 | |
| SCHEMBL19910775 | 0.83 | CHRM2 (0.37) | TGM2NR1H2 | |
| SCHEMBL8607697 | 0.83 | MMP2 (0.40) | NR1H2 | |
| SCHEMBL8609251 | 0.83 | MMP2 (0.40) | NR1H2 | |
| SCHEMBL3382551 | 0.83 | HSD17B10 (0.38) | HSD17B10NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050215603-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | ABBOTT LABORATORIES | 2005-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050215603-A1 | Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV) | DPP4, DPP3, DPP7 | HSD17B10 411/4885HPGD 1557/4885PREP 46/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.