Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.49 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.49 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.43 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | MC5R | P33032 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15970179 | 0.92 | GRIN2B (0.48) | HRH4HRH3TRPM8SLC18A3GRIN2B | |
| SCHEMBL23950410 | 0.86 | NAAA (0.49) | HRH4HRH3SLC18A3GRIN2BALDH1A1 | |
| SCHEMBL31715951 | 0.86 | NAAA (0.49) | HRH4HRH3SLC18A3GRIN2BALDH1A1 | |
| SCHEMBL11251947 | 0.84 | HRH3 (0.67) | HRH4HRH3SLC18A3GRIN2BALDH1A1 | |
| SCHEMBL13280564 | 0.83 | TRPM8 (0.46) | TRPM8ALDH1A1TSHRMC4RMC5R | |
| SCHEMBL531089 | 0.83 | HRH3 (0.70) | HRH4HRH3SLC18A3GRIN2BALDH1A1 | |
| Bromide SCHEMBL11253051 | 0.83 | HRH3 (0.65) | HRH4HRH3SLC18A3GRIN2BALDH1A1 | |
| SCHEMBL16367134 | 0.81 | GRIN2B (0.54) | HRH4HRH3SLC18A3GRIN2BALDH1A1 | |
| SCHEMBL16607846 | 0.81 | GRIN2B (0.54) | HRH4HRH3SLC18A3GRIN2BALDH1A1 | |
| SCHEMBL7603670 | 0.81 | HRH3 (0.73) | HRH4HRH3SLC18A3GRIN2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006009886-A1 | AMINOCYCLOHEXANES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES | MERCK & CO., INC. (US) | 2006-01-26 | — | — | WO | disclosed |