Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 5/20 | 0.52 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18568866 | 0.88 | GAA (0.68) | GAAL3MBTL1FFAR1KDM4EALDH1A1 | |
| SCHEMBL17366180 | 0.86 | GAA (0.55) | GAAL3MBTL1FFAR1KDM4EALDH1A1 | |
| SCHEMBL30121977 | 0.84 | MDM2 (0.64) | GAAMDM2KDM4EALDH1A1TP53 | |
| SCHEMBL8272076 | 0.84 | TP53 (0.59) | GAAMDM2ALDH1A1TP53SMN1; SMN2 | |
| SCHEMBL22781472 | 0.83 | GAA (0.55) | GAAL3MBTL1FFAR1KDM4EALDH1A1 | |
| SCHEMBL17366174 | 0.81 | MDM2 (0.58) | GAAMDM2KDM4EALDH1A1TP53 | |
| SCHEMBL22781218 | 0.81 | DRD4 (0.48) | GAAFFAR1MDM2KDM4EALDH1A1 | |
| SCHEMBL18569320 | 0.79 | GAA (0.56) | GAAL3MBTL1FFAR1KDM4EALDH1A1 | |
| SCHEMBL17366169 | 0.78 | MDM2 (0.58) | GAAMDM2ALDH1A1TP53MAPT | |
| SCHEMBL17366151 | 0.78 | MDM2 (0.58) | GAAMDM2KDM4EALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786773-B1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RES TECH LTD (GB) | 2017-03-01 | — | — | EP | disclosed |
| WO-2006024837-A1 | ISOINDOLIN-1-ONE DERIVATIVES | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2006-03-09 | — | — | WO | disclosed |