Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 4/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CETP | P11597 | 2/20 | 0.34 |
| ▸ | CBLB | Q13191 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD4 | P21917 | 2/20 | 0.33 |
| ▸ | DRD3 | P35462 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8222389 | 0.91 | CHRM4 (0.43) | ADAM17USP30FFAR4PGRCYP2C19 | |
| SCHEMBL8276137 | 0.88 | KDM4E (0.34) | ADAM17USP30CBLBKDM4EALDH1A1 | |
| SCHEMBL8273332 | 0.80 | ADAM17 (0.42) | ADAM17USP30FFAR4CHRM4KDM4E | |
| SCHEMBL8222096 | 0.79 | CHRM4 (0.43) | ADAM17USP30FFAR4CHRM4LDHA | |
| SCHEMBL8222101 | 0.78 | CHRM4 (0.44) | ADAM17USP30FFAR4CHRM4KDM4E | |
| SCHEMBL8217224 | 0.77 | CHRM4 (0.43) | ADAM17USP30FFAR4CETPCHRM4 | |
| SCHEMBL8218328 | 0.77 | CHRM4 (0.42) | ADAM17USP30FFAR4CETPCHRM4 | |
| SCHEMBL8276124 | 0.74 | CHRM4 (0.42) | ADAM17USP30FFAR4CETPCHRM4 | |
| SCHEMBL8215183 | 0.74 | CHRM4 (0.42) | ADAM17USP30FFAR4CETPCHRM4 | |
| SCHEMBL8276983 | 0.74 | ADAM17 (0.45) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |