Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 13/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.34 |
| ▸ | CALCA | P06881 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 1/20 | 0.33 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274428 | 0.90 | ADAM17 (0.49) | ADAM17ACACBKCNH2 | |
| SCHEMBL8222061 | 0.89 | ADAM17 (0.59) | ADAM17ACACB | |
| SCHEMBL8275727 | 0.76 | HRH3 (0.35) | ADAM17HRH3KCNH2CALCAADAMTS5 | |
| SCHEMBL8273310 | 0.75 | GAA (0.44) | ADAM17KCNH2 | |
| SCHEMBL8273592 | 0.74 | HTT (0.46) | ADAM17KCNH2 | |
| SCHEMBL8273348 | 0.73 | ADAM17 (0.53) | ADAM17 | |
| SCHEMBL8221438 | 0.73 | ADAM17 (0.53) | ADAM17 | |
| SCHEMBL8275879 | 0.73 | ADAM17 (0.81) | ADAM17 | |
| SCHEMBL8273591 | 0.73 | ADAM17 (0.43) | ADAM17KCNH2 | |
| SCHEMBL8213698 | 0.73 | ADAM17 (0.53) | ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |