Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8273310 | 0.99 | GAA (0.44) | HTTALDH1A1GAAADAM17KDM4E | |
| SCHEMBL8273591 | 0.97 | ADAM17 (0.43) | HTTALDH1A1GAAADAM17KDM4E | |
| SCHEMBL8273579 | 0.91 | CTSS (0.41) | HTTALDH1A1GAAADAM17KDM4E | |
| SCHEMBL8273588 | 0.91 | ADAM17 (0.40) | HTTALDH1A1GAAADAM17KDM4E | |
| SCHEMBL8274681 | 0.90 | GAA (0.43) | HTTALDH1A1GAAADAM17KDM4E | |
| SCHEMBL8273374 | 0.88 | ALDH1A1 (0.40) | HTTALDH1A1GAAADAM17KDM4E | |
| SCHEMBL8273376 | 0.88 | ALDH1A1 (0.40) | HTTALDH1A1GAAADAM17KDM4E | |
| SCHEMBL8273578 | 0.88 | ADAM17 (0.39) | HTTALDH1A1GAAADAM17KDM4E | |
| SCHEMBL8274407 | 0.88 | ADAM17 (0.43) | HTTALDH1A1GAAADAM17L3MBTL1 | |
| SCHEMBL8276118 | 0.88 | ADAM17 (0.43) | HTTALDH1A1GAAADAM17L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |