Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR3 | O60755 | 19/20 | 0.63 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.63 |
| ▸ | DRD5 | P21918 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL916597 | 0.90 | GALR3 (0.76) | GALR3HTR4DRD5ADRA1ATTR | |
| SCHEMBL916590 | 0.90 | GALR3 (0.76) | GALR3HTR4DRD5ADRA1ATTR | |
| SCHEMBL915968 | 0.87 | GALR3 (0.83) | GALR3HTR4DRD5ADRA1A | |
| SCHEMBL915969 | 0.87 | GALR3 (0.83) | GALR3HTR4DRD5ADRA1A | |
| SCHEMBL8250355 | 0.84 | TTR (0.61) | GALR3HTR4TTR | |
| SCHEMBL8360408 | 0.84 | GALR3 (0.48) | GALR3HTR4TTR | |
| SCHEMBL25275772 | 0.82 | GALR3 (0.57) | GALR3HTR4 | |
| SCHEMBL8171376 | 0.81 | GALR3 (0.69) | GALR3HTR4DRD5ADRA1A | |
| SCHEMBL6905291 | 0.81 | GALR3 (0.65) | GALR3HTR4DRD5TTR | |
| SCHEMBL5357195 | 0.81 | GALR3 (0.53) | GALR3HTR4TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7166635-B2 | 3-imino-2-indolones for the treatment of depression and/or anxiety | H. LUNDBECK A/S (DK) | 2007-01-23 | — | — | US | disclosed |
| US-7166635-B2 | 3-imino-2-indolones for the treatment of depression and/or anxiety | H. LUNDBECK A/S (DK) | 2007-01-23 | — | — | US | disclosed |
| US-20050148635-A1 | 3-imino-2-indolones for the treatment of depression and/or anxiety | SYNAPTIC PHARMACEUTICAL CORPORATION | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050148635-A1 | 3-imino-2-indolones for the treatment of depression and/or anxiety | GALR3, GALR2, GALR1 | GALR3 1/4885HTR4 17/4885DRD5 452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.