Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | NAMPT | P43490 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274753 | 1.00 | ADAM17 (0.42) | ADAM17MEN1KMT2AUSP2GAA | |
| SCHEMBL8275729 | 0.88 | ADAM17 (0.38) | ADAM17MEN1KMT2APSEN1PSEN2 | |
| SCHEMBL8222093 | 0.88 | ADAM17 (0.55) | ADAM17MEN1KMT2ANAMPTHTR1A | |
| SCHEMBL13542433 | 0.81 | ADAM17 (0.38) | ADAM17MEN1KMT2AGAAHTR1A | |
| SCHEMBL8274406 | 0.79 | ADAM17 (0.49) | ADAM17MEN1KMT2AUSP2GAA | |
| SCHEMBL8273741 | 0.79 | ADAM17 (0.48) | ADAM17MEN1KMT2AUSP2GAA | |
| SCHEMBL8275600 | 0.78 | ADAM17 (0.45) | ADAM17MEN1KMT2ANAMPTADAM10 | |
| SCHEMBL8273582 | 0.77 | ADAM17 (0.47) | ADAM17MEN1KMT2AUSP2GAA | |
| SCHEMBL8275453 | 0.76 | ADAM17 (0.44) | ADAM17MEN1KMT2AUSP2GAA | |
| SCHEMBL8275183 | 0.75 | ADAM17 (0.43) | ADAM17MEN1KMT2ANAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |