Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 8/20 | 0.47 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.39 |
| ▸ | MMP12 | P39900 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.35 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8221461 | 0.89 | ADAM17 (0.60) | ADAM17ADAM10MMP12MMP13KDM4E | |
| SCHEMBL8274406 | 0.89 | ADAM17 (0.49) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8273311 | 0.88 | ADAM17 (0.41) | ADAM17MEN1GAAKMT2AKDM4E | |
| SCHEMBL8273741 | 0.84 | ADAM17 (0.48) | ADAM17MEN1USP2GAAKMT2A | |
| SCHEMBL8275453 | 0.83 | ADAM17 (0.44) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8275600 | 0.83 | ADAM17 (0.45) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8222728 | 0.81 | ADAM17 (0.49) | ADAM17KDM1A | |
| SCHEMBL8273312 | 0.80 | ADAM17 (0.41) | ADAM17ADAM10MMP12MMP13MEN1 | |
| SCHEMBL8273578 | 0.78 | ADAM17 (0.39) | ADAM17MEN1GAAKMT2AKDM4E | |
| SCHEMBL8274404 | 0.78 | ADAM17 (0.55) | ADAM17ADAM10MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |