Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 7/20 | 1.00 |
| ▸ | ENTPD5 | O75356 | 3/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.36 |
| ▸ | ST6GAL1 | P15907 | 3/20 | 0.35 |
| ▸ | ST3GAL1 | Q11201 | 2/20 | 0.35 |
| ▸ | ST3GAL3 | Q11203 | 2/20 | 0.35 |
| ▸ | FUT6 | P51993 | 1/20 | 0.33 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Strongylin A SCHEMBL31536139 | 1.00 | CETP (1.00) | CETPENTPD5PTGS2ALOX15ALOX12 | |
| SCHEMBL8148354 | 0.67 | CETP (0.51) | CETPENTPD5ST6GAL1ST3GAL1ST3GAL3 | |
| SCHEMBL31292860 | 0.61 | CETP (0.47) | CETPENTPD5ALOX15ALOX12 | |
| (+/-)-Wiedendiol B SCHEMBL8275931 | 0.60 | CETP (1.00) | CETPPTGS2ALOX15ALOX12PIK3CA | |
| (+/-)-Wiedendiol B SCHEMBL1229327 | 0.60 | CETP (1.00) | CETPPTGS2ALOX15ALOX12PIK3CA | |
| SCHEMBL6658224 | 0.57 | MEN1 (0.44) | CETPALOX15ALOX12KDM4EMEN1 | |
| SCHEMBL6439147 | 0.56 | ADRA1A (0.49) | CETPKDM4EMEN1TP53KMT2A | |
| SCHEMBL12234374 | 0.56 | PIK3CB (0.48) | CETPENTPD5PTGS2ALOX15ALOX12 | |
| SCHEMBL16984748 | 0.54 | CETP (0.39) | CETPENTPD5MEN1CYP3A4KMT2A | |
| SCHEMBL5723031 | 0.54 | PDE4A (0.42) | CETPKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005117869-A1 | COMBINATIONS COMPRISING (S)-AMLODIPINE AND A CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITOR, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-12-15 | — | — | WO | disclosed |