Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.64 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.64 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.64 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.64 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.64 |
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | LMNA | P02545 | 5/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8274000 | 0.89 | SMN1; SMN2 (0.64) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8275420 | 0.86 | HDAC3 (0.66) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14058601 | 0.85 | HDAC3 (0.73) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13988083 | 0.84 | LMNA (0.68) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8276416 | 0.82 | LMNA (0.65) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13988046 | 0.82 | SMN1; SMN2 (0.67) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4871237 | 0.78 | HDAC3 (1.00) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL27180731 | 0.78 | LMNA (0.72) | SMN1; SMN2MAPTLMNAUSP2PKM | |
| SCHEMBL5229664 | 0.77 | MAPT (0.97) | SMN1; SMN2MAPTLMNAPKMALDH1A1 | |
| SCHEMBL27180707 | 0.77 | MAPT (0.77) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470722-B2 | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| US-7470722-B2 | Multicyclic sulfonamide compounds as inhibitors of histone deacetylase for the treatment of disease | KALYPSYS, INC. (US) | 2008-12-30 | — | — | US | disclosed |
| WO-2005123089-A2 | MULTICYCLIC SULFONAMIDE COMPOUNDS AS INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2005-12-29 | — | — | WO | disclosed |