Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.97 |
| ▸ | PKM | P14618 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 5/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | CES1 | P23141 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9968014 | 0.82 | HPGD (0.74) | MAPTPKMMEN1KMT2ALMNA | |
| SCHEMBL8879732 | 0.81 | MAPT (0.67) | MAPTPKMMEN1KMT2ALMNA | |
| SCHEMBL14058601 | 0.81 | HDAC3 (0.73) | MAPTPKMKMT2ALMNASMN1; SMN2 | |
| SCHEMBL10079157 | 0.78 | GFER (0.78) | MAPTPKMMEN1KMT2ALMNA | |
| SCHEMBL13988046 | 0.78 | SMN1; SMN2 (0.67) | MAPTPKMMEN1KMT2ALMNA | |
| SCHEMBL21933241 | 0.78 | MAPT (0.65) | MAPTPKMMEN1KMT2ALMNA | |
| SCHEMBL6522456 | 0.77 | ALDH1A1 (1.00) | MAPTPKMMEN1KMT2ALMNA | |
| SCHEMBL6554630 | 0.77 | CES1 (1.00) | MAPTPKMMEN1KMT2AHTT | |
| SCHEMBL2474197 | 0.77 | CES1 (1.00) | MAPTPKMMEN1KMT2AHTT | |
| SCHEMBL8273997 | 0.77 | SMN1; SMN2 (0.65) | MAPTPKMLMNAHTTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1519932-B1 | BISARYLSULFONAMIDE COMPOUNDS AND THEIR USE IN CANCER THERAPY | CYCLACEL LTD (GB) | 2007-10-03 | — | — | EP | claimed |