Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 20/20 | 0.69 |
| ▸ | MMP13 | P45452 | 2/20 | 0.62 |
| ▸ | ADAM10 | O14672 | 1/20 | 0.62 |
| ▸ | MMP1 | P03956 | 1/20 | 0.62 |
| ▸ | MMP2 | P08253 | 1/20 | 0.62 |
| ▸ | MMP3 | P08254 | 1/20 | 0.62 |
| ▸ | MMP14 | P50281 | 1/20 | 0.62 |
| ▸ | MMP7 | P09237 | 1/20 | 0.58 |
| ▸ | MMP12 | P39900 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12215558 | 0.84 | ADAM17 (0.69) | ADAM17MMP13ADAM10MMP1MMP2 | |
| SCHEMBL8274555 | 0.83 | ADAM17 (0.67) | ADAM17MMP13ADAM10MMP1MMP2 | |
| SCHEMBL8273451 | 0.83 | ADAM17 (0.60) | ADAM17MMP13ADAM10MMP1MMP2 | |
| SCHEMBL8209748 | 0.81 | ADAM17 (1.00) | ADAM17MMP13ADAM10MMP1MMP2 | |
| SCHEMBL8414502 | 0.81 | ADAM17 (0.83) | ADAM17MMP13ADAM10MMP1MMP2 | |
| SCHEMBL11513602 | 0.80 | RIPK1 (0.54) | ADAM17 | |
| SCHEMBL8274486 | 0.79 | ADAM17 (0.82) | ADAM17MMP13ADAM10MMP1MMP2 | |
| SCHEMBL8221690 | 0.79 | ADAM17 (0.78) | ADAM17MMP13ADAM10MMP1MMP2 | |
| SCHEMBL8222354 | 0.78 | ADAM17 (0.61) | ADAM17MMP13ADAM10MMP1MMP2 | |
| SCHEMBL8216012 | 0.78 | ADAM17 (1.00) | ADAM17MMP13ADAM10MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007064749-A1 | COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS AND MICROBIAL DISEASES | SCHERING CORPORATION (US) | 2007-06-07 | — | — | WO | disclosed |
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |