Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 8/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8217041 | 0.85 | CHRM4 (0.47) | CHRM4ADAM17SCN9A | |
| SCHEMBL8222801 | 0.83 | CHRM4 (0.49) | CHRM4ADAM17EPHX2KDM4EPKM | |
| SCHEMBL8224737 | 0.80 | CHRM4 (0.41) | CHRM4ADAM17EPHX2 | |
| SCHEMBL8221943 | 0.79 | CHRM4 (0.43) | CHRM4ADAM17 | |
| SCHEMBL8217133 | 0.79 | CHRM4 (0.49) | CHRM4ADAM17EPHX2CHRM2 | |
| SCHEMBL8222066 | 0.79 | CHRM4 (0.45) | CHRM4ADAM17EPHX2KDM4EPKM | |
| SCHEMBL8221929 | 0.79 | CHRM4 (0.44) | CHRM4ADAM17EPHX2SCN9A | |
| SCHEMBL8223335 | 0.77 | CHRM4 (0.43) | CHRM4ADAM17EPHX2SCN9A | |
| SCHEMBL8217012 | 0.75 | HTR1A (0.47) | ADAM17KDM4E | |
| SCHEMBL8275932 | 0.74 | CHRM4 (0.45) | CHRM4ADAM17 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005121130-A2 | CHEMICAL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FOR THE TREATMENT OF INFLAMMATORY DISORDERS | SCHERING CORPORATION (US) | 2005-12-22 | — | — | WO | disclosed |