Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.35 |
| ▸ | PLAT | P00750 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | SHBG | P04278 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8277925 | 1.00 | NCF1 (0.38) | NCF1PLGPLATLMNASHBG | |
| SCHEMBL14445045 | 1.00 | NCF1 (0.38) | NCF1PLGPLATLMNASHBG | |
| SCHEMBL4967235 | 0.84 | NCF1 (0.39) | NCF1PLGPLATLMNA | |
| SCHEMBL1193150 | 0.83 | — | — | |
| SCHEMBL8675545 | 0.83 | SHBG (0.42) | SHBG | |
| SCHEMBL10581559 | 0.80 | NCF1 (0.37) | NCF1PLGPLATLMNA | |
| SCHEMBL70093 | 0.78 | NCF1 (0.42) | NCF1PLGPLATLMNA | |
| SCHEMBL8275064 | 0.78 | NCF1 (0.42) | NCF1PLGPLATLMNA | |
| SCHEMBL10216772 | 0.78 | NCF1 (0.42) | NCF1PLGPLATLMNA | |
| SCHEMBL4917793 | 0.77 | SHBG (0.37) | SHBG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773775-B1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2011-08-17 | — | — | EP | disclosed |
| WO-2005123680-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-12-29 | — | — | WO | disclosed |