Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.37 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655620 | 0.80 | GAA (0.59) | GAATHRBATML3MBTL1NOS3 | |
| SCHEMBL655621 | 0.80 | GAA (0.59) | GAATHRBATML3MBTL1NOS3 | |
| SCHEMBL702046 | 0.80 | GAA (0.59) | GAATHRBATML3MBTL1NOS3 | |
| SCHEMBL4592901 | 0.76 | MAPT (0.59) | GAATHRBATML3MBTL1NOS3 | |
| SCHEMBL14413081 | 0.76 | KMT2A (0.57) | GAAGNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL3403317 | 0.73 | GNAI3 (0.49) | MAPTGNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL15731364 | 0.73 | GNAI3 (0.49) | MAPTGNAI3GNAO1GNAI1ALDH1A1 | |
| SCHEMBL13648185 | 0.73 | POLB (0.52) | GNAI3GNAO1GNAI1 | |
| SCHEMBL31654701 | 0.73 | POLB (0.52) | GNAI3GNAO1GNAI1 | |
| SCHEMBL382565 | 0.73 | GAA (0.68) | GAATHRBATML3MBTL1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005118534-A1 | CIS PYRROLIDINYL DERIVATIVES AND THEIR USES | FAUST PHARMACEUTICALS (FR) | 2005-12-15 | — | — | WO | disclosed |