Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | SNCA | P37840 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CCR6 | P51684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8275987 | 0.93 | MAPT (0.38) | MAOBMAOANPC1MAPTRAB9A | |
| SCHEMBL13933071 | 0.83 | PIK3CA (0.31) | NPC1RAB9ACISD1 | |
| SCHEMBL4248380 | 0.81 | CISD1 (0.37) | MAOBMAOAMAPTCISD1SLC6A3 | |
| SCHEMBL4252191 | 0.77 | CISD1 (0.33) | CISD1 | |
| SCHEMBL3931293 | 0.76 | CISD1 (0.34) | NPC1RAB9ACISD1ALDH1A1ALOX12 | |
| SCHEMBL4010167 | 0.76 | RXFP1 (0.37) | MAOBMAOAATMCISD1SLC6A3 | |
| SCHEMBL4252684 | 0.75 | LDHA (0.37) | MAPTCISD1ALDH1A1 | |
| SCHEMBL4248014 | 0.74 | MAOB (0.38) | MAOBCISD1SLC6A3ALDH1A1LMNA | |
| SCHEMBL4248198 | 0.74 | CISD1 (0.33) | CISD1 | |
| SCHEMBL2798454 | 0.73 | CTSD (0.40) | CISD1SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758907-B1 | DIPHENYLIMIDAZOPYRIMIDINE AND -IMIDAZOLE AMINES AS INHIBITORS OF B-SECRETASE | WYETH CORP (US) | 2009-02-18 | — | — | EP | disclosed |
| US-20090042912-A1 | DIPHENYLIMIDAZOLYL COMPOUNDS AS INHIBITORS OF beta-SECRETASE | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-20090042912-A1 | DIPHENYLIMIDAZOLYL COMPOUNDS AS INHIBITORS OF beta-SECRETASE | WYETH (US) | 2009-02-12 | — | — | US | disclosed |
| US-7456186-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456186-B2 | Diphenylimidazopyrimidines as inhibitors of β-secretase | WYETH (US) | 2008-11-25 | — | — | US | disclosed |
| WO-2006009655-A1 | DIPHENYLIMIDAZOPYRIMIDINE AND -IMIDAZOLE AMINES AS INHIBITORS OF B-SECRETASE | WYETH (US) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090042912-A1 | DIPHENYLIMIDAZOLYL COMPOUNDS AS INHIBITORS OF beta-SECRETASE | BACE1, BACE2, APP | MAOB 784/4885MAOA 884/4885SNCA 197/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.