Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.50 |
| ▸ | ITK | Q08881 | 1/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.49 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | NEK1 | Q96PY6 | 5/20 | 0.45 |
| ▸ | AXL | P30530 | 5/20 | 0.45 |
| ▸ | SGK1 | O00141 | 4/20 | 0.45 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314581 | 0.88 | SGK1 (0.62) | BTKITKMAPK8MAPK9MAPK10 | |
| SCHEMBL8442334 | 0.82 | AXL (0.54) | ITKMAPK8MAPK9MAPK10PDPK1 | |
| SCHEMBL8281203 | 0.82 | CDK8 (0.54) | BTKITKIMPDH2NEK1AXL | |
| SCHEMBL2181151 | 0.81 | BTK (0.45) | BTKITKIMPDH2NEK1AXL | |
| SCHEMBL13357059 | 0.81 | MAPK8 (0.49) | MAPK8MAPK9MAPK10PDPK1PIK3CA | |
| SCHEMBL7971778 | 0.77 | AXL (0.56) | BTKITKMAPK8MAPK9MAPK10 | |
| SCHEMBL8281297 | 0.75 | JAK1 (0.48) | MAPK8MAPK9MAPK10DYRK1ACLK1 | |
| SCHEMBL8281313 | 0.75 | JAK1 (0.48) | MAPK8MAPK9MAPK10DYRK1ACLK1 | |
| SCHEMBL8281331 | 0.75 | PDPK1 (0.49) | MAPK8MAPK9MAPK10PDPK1AXL | |
| SCHEMBL3346633 | 0.75 | PRKD3 (0.52) | BTKMAPK8MAPK9MAPK10AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| WO-2005085244-A1 | 3,5-DISUBSTITUTED 1H-PZRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI LONDON RESEARCH LABORATORIES LIMITED (GB) | 2005-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | API5, CDK5, MAPKAPK5 | BTK 1875/4885ITK 2541/4885MAPK8 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.