Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 5/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.52 |
| ▸ | AXL | P30530 | 5/20 | 0.52 |
| ▸ | FLT4 | P35916 | 5/20 | 0.52 |
| ▸ | FLT3 | P36888 | 5/20 | 0.52 |
| ▸ | CLK2 | P49760 | 5/20 | 0.52 |
| ▸ | MAP4K2 | Q12851 | 5/20 | 0.52 |
| ▸ | CAMK2B | Q13554 | 5/20 | 0.52 |
| ▸ | CAMK2G | Q13555 | 5/20 | 0.52 |
| ▸ | CAMK2D | Q13557 | 5/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 5/20 | 0.52 |
| ▸ | NTRK3 | Q16288 | 5/20 | 0.52 |
| ▸ | PKN2 | Q16513 | 5/20 | 0.52 |
| ▸ | MINK1 | Q8N4C8 | 5/20 | 0.52 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.52 |
| ▸ | SLK | Q9H2G2 | 5/20 | 0.52 |
| ▸ | CLK4 | Q9HAZ1 | 5/20 | 0.52 |
| ▸ | MKNK2 | Q9HBH9 | 5/20 | 0.52 |
| ▸ | SGK2 | Q9HBY8 | 5/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442154 | 0.83 | MAPK9 (0.47) | PRKD3MAP4K4NTRK1AXLFLT4 | |
| SCHEMBL8443958 | 0.82 | DYRK1A (0.73) | PRKD3MAP4K4NTRK1AXLFLT4 | |
| SCHEMBL8442334 | 0.81 | AXL (0.54) | PRKD3NTRK1AXLFLT4FLT3 | |
| SCHEMBL3349513 | 0.79 | CDK8 (0.62) | PRKD3MAP4K4NTRK1AXLFLT4 | |
| SCHEMBL3351160 | 0.77 | MAPK8 (0.56) | AXLCLK2CLK4MAPK9AURKB | |
| SCHEMBL8320085 | 0.76 | AXL (0.76) | AXLMAPK9DYRK1AMAPK8MAPK10 | |
| SCHEMBL8280140 | 0.75 | BTK (0.50) | AXLBTKMAPK9DYRK1AMAPK8 | |
| SCHEMBL8320090 | 0.75 | AXL (0.62) | PRKD3MAP4K4NTRK1AXLFLT4 | |
| SCHEMBL8320389 | 0.75 | DYRK1A (0.66) | PRKD3MAP4K4AXLFLT4FLT3 | |
| SCHEMBL3349599 | 0.75 | MAPK8 (0.56) | NTRK1AXLMAPK9AURKBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |
| US-20100035878-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS RELATING TO APOPTOSIS AND/OR INFLAMMATION | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2010-02-11 | — | — | US | disclosed |
| US-7645769-B2 | Inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders relating to apoptosis and/or inflammation | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2010-01-12 | — | — | US | disclosed |
| US-20070072896-A1 | Inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders relating to apoptosis and/or inflammation | EISAI CO., LTD. (JP) | 2007-03-29 | — | — | US | disclosed |
| EP-1749829-A1 | JNK inhibitors | Eisai London Research Laboratories Limited (GB) | 2007-02-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035878-A1 | INHIBITORS OF C-JUN N-TERMINAL KINASES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS RELATING TO APOPTOSIS AND/OR INFLAMMATION | NFKBIA, CHUK, MAP3K1 | PRKD3 188/4885MAP4K4 87/4885NTRK1 1216/4885 |
| US-20070072896-A1 | Inhibitors of c-Jun N-terminal kinases for the treatment of neurodegenerative disorders relating to apoptosis and/or inflammation | NFKBIA, CHUK, MAP3K1 | PRKD3 188/4885MAP4K4 87/4885NTRK1 1216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.