Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 10/20 | 0.54 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.54 |
| ▸ | SGK1 | O00141 | 3/20 | 0.54 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.49 |
| ▸ | CLK1 | P49759 | 2/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.49 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320085 | 0.86 | AXL (0.76) | AXLCAMKK2SGK1MAPK8MAPK9 | |
| SCHEMBL8280140 | 0.82 | BTK (0.50) | AXLCAMKK2SGK1MAPK8MAPK9 | |
| SCHEMBL8281331 | 0.81 | PDPK1 (0.49) | AXLMAPK8MAPK9MAPK10DYRK1A | |
| SCHEMBL8281313 | 0.81 | JAK1 (0.48) | MAPK8MAPK9MAPK10DYRK1ACLK1 | |
| SCHEMBL8281297 | 0.81 | JAK1 (0.48) | MAPK8MAPK9MAPK10DYRK1ACLK1 | |
| SCHEMBL3346633 | 0.81 | PRKD3 (0.52) | AXLMAPK8MAPK9MAPK10DYRK1A | |
| SCHEMBL8281311 | 0.80 | JAK1 (0.48) | MAPK8MAPK9MAPK10DYRK1ACLK1 | |
| SCHEMBL3351160 | 0.80 | MAPK8 (0.56) | AXLMAPK8MAPK9MAPK10DYRK1A | |
| SCHEMBL8281322 | 0.80 | JAK1 (0.48) | MAPK8MAPK9MAPK10DYRK1ACLK1 | |
| SCHEMBL13357059 | 0.80 | MAPK8 (0.49) | AXLCAMKK2SGK1MAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1749829-B1 | JNK inhibitors | EISAI R&D MAN CO LTD (JP) | 2010-11-03 | — | — | EP | disclosed |
| EP-1749829-A1 | JNK inhibitors | Eisai London Research Laboratories Limited (GB) | 2007-02-07 | — | — | EP | disclosed |