Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7780070 | 0.80 | MAPT (0.39) | MAPTALDH1A1LMNAPOLBATM | |
| SCHEMBL8280386 | 0.74 | MAPT (0.46) | MAPTALDH1A1LMNAPOLBATM | |
| SCHEMBL9480370 | 0.66 | MAPT (0.43) | MAPTALDH1A1POLBATMMEN1 | |
| SCHEMBL14899780 | 0.66 | MAPT (0.41) | MAPTALDH1A1LMNAPOLBATM | |
| SCHEMBL9638790 | 0.63 | MAPT (0.49) | MAPTALDH1A1POLBATMMEN1 | |
| SCHEMBL28848233 | 0.62 | ALDH1A1 (0.43) | MAPTALDH1A1LMNAPOLBATM | |
| SCHEMBL8919153 | 0.62 | ALDH1A1 (0.39) | MAPTALDH1A1LMNAPOLBATM | |
| SCHEMBL10811620 | 0.62 | MAPT (0.42) | MAPTALDH1A1POLBATMMEN1 | |
| SCHEMBL4776141 | 0.61 | POLB (0.43) | MAPTALDH1A1POLBATMMEN1 | |
| SCHEMBL9498739 | 0.61 | MAPT (0.69) | MAPTALDH1A1L3MBTL1MEN1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005077915-A1 | PYRIDAZINONES AS ANTAGONISTS OF A4 INTEGRINS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-08-25 | — | — | WO | disclosed |