SCHEMBL8280922

SCHEMBL8280922

COCc1nnc(-c2ccc(O)cc2OC)n1-c1ccc(OC)nc1

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
OXTR P30559 20/20 0.63
AVPR1A P37288 19/20 0.63
AVPR2 P30518 5/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8282558 0.87 OXTR (0.62) OXTRAVPR1AAVPR2
SCHEMBL930785 0.84 OXTR (0.62) OXTRAVPR1AAVPR2
SCHEMBL8282060 0.83 OXTR (0.46) OXTRAVPR1AAVPR2
SCHEMBL8282062 0.83 OXTR (0.61) OXTRAVPR1AAVPR2
SCHEMBL8282006 0.83 OXTR (0.72) OXTRAVPR1AAVPR2
SCHEMBL8282035 0.81 OXTR (0.69) OXTRAVPR1AAVPR2
SCHEMBL931225 0.80 OXTR (0.60) OXTRAVPR1AAVPR2
SCHEMBL930709 0.78 OXTR (0.60) OXTRAVPR1AAVPR2
SCHEMBL5116714 0.77 OXTR (1.00) OXTRAVPR1AAVPR2
SCHEMBL8295600 0.77 OXTR (0.48) OXTRAVPR1AAVPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082866-A2 SUBSTITUTED 1, 2, 4- TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS PFIZER LIMITED (GB) 2005-09-09 WO disclosed