SCHEMBL8282006

SCHEMBL8282006

COCc1nnc(-c2ccc(O)cc2)n1-c1ccc(OC)nc1

nearest known ligand 0.72

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
OXTR P30559 20/20 0.72
AVPR1A P37288 18/20 0.72
AVPR2 P30518 6/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5112336 0.89 OXTR (0.71) OXTRAVPR1AAVPR2
SCHEMBL8282035 0.86 OXTR (0.69) OXTRAVPR1AAVPR2
SCHEMBL5122145 0.85 OXTR (0.82) OXTRAVPR1AAVPR2
SCHEMBL5116714 0.84 OXTR (1.00) OXTRAVPR1AAVPR2
SCHEMBL8281628 0.83 OXTR (0.70) OXTRAVPR1AAVPR2
SCHEMBL5116687 0.83 OXTR (0.67) OXTRAVPR1AAVPR2
SCHEMBL8280922 0.83 OXTR (0.63) OXTRAVPR1AAVPR2
SCHEMBL932296 0.80 OXTR (0.65) OXTRAVPR1AAVPR2
SCHEMBL5115490 0.80 OXTR (0.70) OXTRAVPR1AAVPR2
SCHEMBL8280934 0.80 OXTR (0.81) OXTRAVPR1AAVPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082866-A2 SUBSTITUTED 1, 2, 4- TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS PFIZER LIMITED (GB) 2005-09-09 WO disclosed