SCHEMBL8281027

SCHEMBL8281027

CCOCc1nnc(-c2ccc(OCC)c(C)c2)n1-c1ccc(OC)nc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
OXTR P30559 19/20 1.00
AVPR1A P37288 15/20 1.00
AVPR2 P30518 7/20 0.85
AVPR1B P47901 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6512287 0.92 OXTR (1.00) OXTRAVPR1AAVPR2
SCHEMBL6510715 0.90 OXTR (0.87) OXTRAVPR1AAVPR2AVPR1B
SCHEMBL8282084 0.89 OXTR (0.81) OXTRAVPR1AAVPR2
SCHEMBL8282112 0.86 OXTR (1.00) OXTRAVPR1AAVPR2
SCHEMBL8282609 0.86 OXTR (1.00) OXTRAVPR1AAVPR2
SCHEMBL8280934 0.83 OXTR (0.81) OXTRAVPR1AAVPR2
SCHEMBL8282116 0.82 OXTR (0.75) OXTRAVPR1AAVPR2
SCHEMBL931755 0.79 OXTR (0.65) OXTRAVPR1AAVPR2AVPR1B
SCHEMBL8281748 0.77 OXTR (0.62) OXTRAVPR1AAVPR2AVPR1B
SCHEMBL8281024 0.77 OXTR (0.62) OXTRAVPR1AAVPR2AVPR1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2005082866-A2 SUBSTITUTED 1, 2, 4- TRIAZOLE DERIVATIVES AS OXYTOCIN ANTAGONISTS PFIZER LIMITED (GB) 2005-09-09 WO disclosed