Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 4/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.33 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17947385 | 0.85 | LMNA (0.45) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL8257922 | 0.85 | LMNA (0.45) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL13862134 | 0.85 | CYP3A4 (0.46) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL15787308 | 0.81 | ADRB1 (0.42) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL15787309 | 0.81 | ADRB1 (0.42) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL8251464 | 0.78 | UGT2B7 (0.45) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL16956357 | 0.77 | DAO (0.33) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL639301 | 0.76 | AKR1C3 (0.40) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL639829 | 0.76 | AKR1C3 (0.40) | ADRA2AADRA2BADRA2CADRB1ADRB3 | |
| SCHEMBL10178370 | 0.76 | ADRB1 (0.39) | ADRA2AADRA2BADRA2CADRB1ADRB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005103055-A1 | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |