Known targets — ChEMBL curated mechanism
PSMA1PSMA2PSMA3PSMA4PSMA5PSMA6PSMA7PSMA8PSMB1PSMB10PSMB11PSMB2PSMB3PSMB4PSMB5PSMB6PSMB7PSMB8PSMB9
The experimentally established mechanism targets of Marizomib. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 known ✓ | P28074 | 16/20 | 1.00 |
| ▸ | PSMB1 known ✓ | P20618 | 10/20 | 1.00 |
| ▸ | PSMB2 known ✓ | P49721 | 10/20 | 1.00 |
| ▸ | PSMB11 known ✓ | A5LHX3 | 9/20 | 1.00 |
| ▸ | PSMA7 known ✓ | O14818 | 9/20 | 1.00 |
| ▸ | PSMA1 known ✓ | P25786 | 9/20 | 1.00 |
| ▸ | PSMA2 known ✓ | P25787 | 9/20 | 1.00 |
| ▸ | PSMA3 known ✓ | P25788 | 9/20 | 1.00 |
| ▸ | PSMA4 known ✓ | P25789 | 9/20 | 1.00 |
| ▸ | PSMB8 known ✓ | P28062 | 9/20 | 1.00 |
| ▸ | PSMB9 known ✓ | P28065 | 9/20 | 1.00 |
| ▸ | PSMA5 known ✓ | P28066 | 9/20 | 1.00 |
| ▸ | PSMB4 known ✓ | P28070 | 9/20 | 1.00 |
| ▸ | PSMB6 known ✓ | P28072 | 9/20 | 1.00 |
| ▸ | PSMB10 known ✓ | P40306 | 9/20 | 1.00 |
| ▸ | PSMB3 known ✓ | P49720 | 9/20 | 1.00 |
| ▸ | PSMA6 known ✓ | P60900 | 9/20 | 1.00 |
| ▸ | PSMA8 known ✓ | Q8TAA3 | 9/20 | 1.00 |
| ▸ | PSMB7 known ✓ | Q99436 | 9/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Marizomib SCHEMBL10304713 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL10303952 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL14578927 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL22590161 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL23612709 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL6379440 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL23249771 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL23612710 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL22203978 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 | |
| Marizomib SCHEMBL209546 | 1.00 | PSMB5 (1.00) | PSMB5PSMB1PSMB2PSMB11PSMA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005113558-A2 | SIMPLE STEREOCONTROLLED SYNTHESIS OF SALINOSPORAMIDE A | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2005-12-01 | — | — | WO | disclosed |