Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.49 |
| ▸ | JAK2 | O60674 | 3/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | CLK1 | P49759 | 2/20 | 0.46 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8281307 | 1.00 | JAK1 (0.49) | JAK1JAK2ROCK2RIPK1DYRK1A | |
| SCHEMBL8281324 | 0.99 | JAK1 (0.48) | JAK1JAK2ROCK2RIPK1DYRK1A | |
| SCHEMBL8281322 | 0.97 | JAK1 (0.48) | JAK1JAK2ROCK2RIPK1DYRK1A | |
| SCHEMBL8281331 | 0.94 | PDPK1 (0.49) | JAK1JAK2ROCK2RIPK1DYRK1A | |
| SCHEMBL8321373 | 0.83 | MAPK8 (0.57) | ROCK2RIPK1DYRK1ACLK1DYRK1B | |
| SCHEMBL8281973 | 0.82 | CDK8 (0.51) | RIPK1DYRK1ACLK1DYRK1BPDPK1 | |
| SCHEMBL13357017 | 0.82 | JAK1 (0.47) | JAK1JAK2ROCK2RIPK1DYRK1A | |
| SCHEMBL8281318 | 0.80 | ROCK2 (0.52) | ROCK2DYRK1ACLK1DYRK1BPDPK1 | |
| SCHEMBL8442334 | 0.79 | AXL (0.54) | ROCK2DYRK1ACLK1DYRK1BPDPK1 | |
| SCHEMBL8281311 | 0.78 | JAK1 (0.48) | JAK1ROCK2DYRK1ACLK1DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI CO., LTD. (JP) | 2011-07-07 | — | — | US | disclosed |
| EP-1720871-B1 | 3,5-DISUBSTITUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI R&D MAN CO LTD (JP) | 2010-05-19 | — | — | EP | disclosed |
| WO-2005085244-A1 | 3,5-DISUBSTITUTED 1H-PZRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | EISAI LONDON RESEARCH LABORATORIES LIMITED (GB) | 2005-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166173-A1 | 3,5-DISUBSTUTUTED 1H-PYRROLO [2,3-B] PYRIDINES AS JNK INHIBITORS | API5, CDK5, MAPKAPK5 | JAK1 544/4885JAK2 1014/4885ROCK2 969/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.