Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 10/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CCR6 | P51684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12021977 | 0.83 | HDAC4 (0.43) | HPGDSHDAC4HDAC6HDAC1HDAC5 | |
| SCHEMBL12021840 | 0.81 | HDAC4 (0.41) | HDAC4HDAC6HDAC1 | |
| SCHEMBL8221535 | 0.81 | ABCB1 (0.44) | HPGDSHDAC4HDAC6HDAC1ABCB1 | |
| SCHEMBL14741890 | 0.78 | RAB9A (0.44) | LMNACYP2C9CYP2C19HDAC1 | |
| SCHEMBL8282433 | 0.78 | L3MBTL1 (0.57) | LMNAMAPTCYP2C9CYP2C19ESR2 | |
| SCHEMBL8281144 | 0.75 | HSD17B10 (0.39) | LMNAMAPTCYP2C9CYP2C19ESR2 | |
| SCHEMBL8226451 | 0.74 | NPY2R (0.41) | HPGDSHSD17B10HDAC4HDAC6HDAC1 | |
| SCHEMBL16646800 | 0.74 | HTT (0.47) | LMNAMAPTCYP2C9CYP2C19ESR2 | |
| SCHEMBL8282776 | 0.74 | ACACB (0.48) | LMNAMAPTCYP2C9CYP2C19ESR2 | |
| SCHEMBL13451193 | 0.73 | NPC1 (0.45) | LMNAMAPTCYP2C9CYP2C19ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934227-B1 | 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-1745047-B1 | PYRAZOLO[4,3-E]-1,2,4-TRIAZOLO[1,5-C]PYRIMIDINE ADENOSINE-A2A- RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2010-03-24 | — | — | EP | disclosed |
| WO-2007035542-A1 | 2-HETEROARYL-PYRAZOLO-[4, 3-e]-1, 2, 4-TRIAZOLO-[1,5-c]-PYRIMIDINE AS ADENOSINE A2a RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2007-03-29 | — | — | WO | disclosed |
| WO-2005103055-A1 | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |