Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 12/20 | 0.92 |
| ▸ | PDGFRA | P16234 | 12/20 | 0.92 |
| ▸ | BCR | P11274 | 9/20 | 0.92 |
| ▸ | PDGFRB | P09619 | 7/20 | 0.92 |
| ▸ | PRKCA | P17252 | 4/20 | 0.92 |
| ▸ | EGFR | P00533 | 3/20 | 0.73 |
| ▸ | KIT | P10721 | 4/20 | 0.63 |
| ▸ | JAK3 | P52333 | 1/20 | 0.61 |
| ▸ | BTK | Q06187 | 1/20 | 0.61 |
| ▸ | ITK | Q08881 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9666 | 0.96 | PDGFRA (1.00) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL4896195 | 0.87 | ABL1 (0.84) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL4892567 | 0.85 | ABL1 (0.84) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL4903174 | 0.85 | ABL1 (0.79) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL27841120 | 0.85 | ABL1 (0.79) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL9338 | 0.84 | ABL1 (1.00) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL3219529 | 0.84 | ABL1 (0.77) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL4900131 | 0.83 | PDGFRA (0.77) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL28381450 | 0.83 | ABL1 (0.74) | ABL1PDGFRABCRPDGFRBPRKCA | |
| SCHEMBL4901273 | 0.83 | ABL1 (0.76) | ABL1PDGFRABCRPDGFRBPRKCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564409-B1 | Pyrimidin derivatives and process for their preparation | NOVARTIS AG (CH) | 2000-01-19 | — | — | EP | disclosed |
| EP-0564409-A1 | Pyrimidin derivatives and process for their preparation | CIBA-GEIGY AG (CH) | 1993-10-06 | — | — | EP | disclosed |