Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.49 |
| ▸ | ACACB | O00763 | 1/20 | 0.43 |
| ▸ | ACACA | Q13085 | 1/20 | 0.43 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.40 |
| ▸ | PPARA | Q07869 | 10/20 | 0.39 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.37 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.37 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5521060 | 0.98 | ACLY (0.51) | ACLYACACBACACALTB4RPPARA | |
| SCHEMBL22804027 | 0.87 | ACLY (0.62) | ACLYACACBACACALTB4RPPARA | |
| Gemcabene SCHEMBL761631 | 0.87 | ACLY (0.55) | ACLYACACBACACALTB4RPPARA | |
| SCHEMBL5442799 | 0.86 | ACLY (0.41) | ACLYACACBACACAPPARATTR | |
| Gemcabene SCHEMBL528316 | 0.85 | ACLY (0.53) | ACLYACACBACACALTB4RPPARA | |
| SCHEMBL6258161 | 0.85 | ACLY (0.53) | ACLYACACBACACALTB4RPPARA | |
| SCHEMBL5531453 | 0.85 | ACLY (0.59) | ACLYACACBACACALTB4RPPARA | |
| Gemcabene SCHEMBL4184554 | 0.85 | ACLY (0.53) | ACLYACACBACACALTB4RPPARA | |
| SCHEMBL14269711 | 0.85 | ACLY (0.59) | ACLYACACBACACALTB4RPPARA | |
| SCHEMBL5524941 | 0.85 | ACLY (0.59) | ACLYACACBACACALTB4RPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005097191-A2 | COMBINATIONS COMPRISING (S)- AMLODIPINE AND A HMG-CoA REDUCTASE INHIBITOR OR CHOLESTEROL ABSORPOTION INHIBITOR OR BOTH, AND METHODS FOR REDUCING HYPERTENSION | SEPRACOR INC. (US) | 2005-10-20 | — | — | WO | disclosed |