Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 6/20 | 0.45 |
| ▸ | DRD2 | P14416 | 5/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | PRPS1 | P60891 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | XBP1 | P17861 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL829158 | 0.81 | IDO1 (0.44) | MTNR1AMTNR1BIDO1PRPS1HTT | |
| SCHEMBL2643515 | 0.80 | IDO1 (0.50) | IDO1PRPS1HTTKDM4E | |
| SCHEMBL2643685 | 0.78 | IDO1 (0.48) | IDO1PRPS1HTTKDM4E | |
| SCHEMBL2643415 | 0.77 | IDO1 (0.47) | MTNR1AMTNR1BIDO1PRPS1HTT | |
| SCHEMBL613191 | 0.77 | KDM4E (0.49) | MTNR1AMTNR1BIDO1PRPS1HTT | |
| SCHEMBL3191408 | 0.76 | HTT (0.42) | IDO1HTTKDM4EALDH1A1MEN1 | |
| SCHEMBL614789 | 0.75 | KDM4E (0.49) | IDO1HTTKDM4EMEN1KMT2A | |
| SCHEMBL7671707 | 0.75 | KMO (0.54) | MTNR1AMTNR1BIDO1DRD2BRD4 | |
| SCHEMBL2643394 | 0.74 | KDM4E (0.45) | IDO1HTTKDM4EMEN1KMT2A | |
| SCHEMBL829476 | 0.74 | CPT1A (0.41) | PRPS1ALDH1A1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143281-B2 | Indoles | HOFFMANN-LA ROCHE INC. (US) | 2012-03-27 | — | — | US | disclosed |
| EP-2125785-B1 | INDOLE-3-YL-CARBONYL-PIPERIDINE- DERIVATIVES FOR THE TREATMENT OF ANXIETY AND DEPRESSIVE DISORDERS VIA V1A RECEPTOR ANTAGONISM | HOFFMANN LA ROCHE (CH) | 2011-11-16 | — | — | EP | disclosed |
| WO-2011132443-A1 | SURFACE ACOUSTIC WAVE DEVICE AND MANUFACTURING METHOD OF SAME | 株式会社村田製作所 (JP) | 2011-10-27 | — | — | WO | disclosed |
| US-20080167344-A1 | INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-07-10 | — | — | US | disclosed |
| US-20080161315-A1 | INDOLES | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
| US-20080161316-A1 | INDOLES | HOFFMANN-LA ROCHE, INC. | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161315-A1 | INDOLES | AVPR1A, HTR1A, AVPR1B | MTNR1A 85/4885MTNR1B 221/4885IDO1 17/4885 |
| US-20080167344-A1 | INDOLES | AVPR1A, HTR1A, AVPR1B | MTNR1A 85/4885MTNR1B 221/4885IDO1 17/4885 |
| US-20080161316-A1 | INDOLES | AVPR1A, HTR1A, AVPR1B | MTNR1A 85/4885MTNR1B 221/4885IDO1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.