Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 2/20 | 0.32 |
| ▸ | DAO | P14920 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.31 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.31 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.31 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13264008 | 1.00 | PDE2A (0.32) | PDE2ADAOADRA2AADRA2BADRA2C | |
| SCHEMBL24800843 | 0.88 | PDE2A (0.33) | PDE2AADRB2ADRB1ADRB3 | |
| SCHEMBL8251555 | 0.86 | PDE2A (0.36) | PDE2ADAOADRA2AADRA2BADRA2C | |
| SCHEMBL19420218 | 0.83 | LMNA (0.33) | PDE2A | |
| SCHEMBL8257851 | 0.82 | PDE2A (0.36) | PDE2ADAOADRA2AADRA2BADRA2C | |
| SCHEMBL12648684 | 0.81 | GABRA1 (0.34) | — | |
| SCHEMBL6742606 | 0.81 | KDM1A (0.33) | PDE2A | |
| SCHEMBL20812098 | 0.79 | PDE2A (0.30) | PDE2A | |
| SCHEMBL13265231 | 0.77 | PDE2A (0.46) | PDE2AADRA2AADRA2BADRA2CADRB2 | |
| SCHEMBL17215436 | 0.73 | PDE2A (0.39) | PDE2AADRA2AADRA2BADRA2CADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005103055-A1 | PYRAZOLO-[4,3-e]-1,2,4-TRIAZOLO-[1,5-c]-PYRIMIDINE ADENOSINE A2A RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 2005-11-03 | — | — | WO | disclosed |