Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NCEH1 | Q6PIU2 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | SELE | P16581 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | AKT2 | P31751 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17005394 | 0.85 | MLYCD (0.43) | MLYCD | |
| SCHEMBL19330134 | 0.81 | KDM4E (0.56) | MLYCDCLK1DYRK1ADYRK1BKMT2A | |
| SCHEMBL7077559 | 0.81 | MLYCD (0.44) | MLYCDCLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL4778395 | 0.81 | MLYCD (0.44) | MLYCDCLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL29632636 | 0.80 | SMN1; SMN2 (0.41) | MEN1KMT2ATDP1KDM4EALDH1A1 | |
| SCHEMBL39608 | 0.80 | MLYCD (0.41) | MLYCDCLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL361909 | 0.79 | MLYCD (0.42) | MLYCDCLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL1367620 | 0.78 | MLYCD (0.41) | MLYCDCLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL24664552 | 0.76 | MLYCD (0.44) | MLYCDCLK1DYRK1ADYRK1BMEN1 | |
| SCHEMBL15100737 | 0.76 | MLYCD (0.41) | MLYCDCLK1DYRK1ADYRK1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240043435-A1 | TYK-2 INHIBITOR | BEONE MEDICINES I GMBH (CH) | 2024-02-08 | — | — | US | disclosed |
| EP-4168398-A1 | TYK-2 INHIBITOR | BeiGene, Ltd. (KY) | 2023-04-26 | — | — | EP | disclosed |
| CN-115715288-A | TYK-2 inhibitors | 百济神州有限公司 | 2023-02-24 | — | — | CN | disclosed |
| WO-2021259208-A1 | TYK-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-12-30 | — | — | WO | disclosed |
| WO-2005084439-A1 | 2-PYRIDINYL[7-(SUBSTITUTED-PYRIDIN-4-YL) PYRAZOLO[1,5-A]PYRIMIDIN-3-YL]METHANONES | DOV PHARMACEUTICAL, INC. (US) | 2005-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240043435-A1 | TYK-2 INHIBITOR | TYK2, IRAK2, PTK2B | MLYCD 2291/4885CLK1 539/4885DYRK1A 88/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.