Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | GRM5 | P41594 | 7/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | G6PD | P11413 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5046079 | 0.80 | ALDH1A1 (0.60) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL4433042 | 0.80 | ALDH1A1 (0.52) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL4421502 | 0.80 | POLB (0.57) | ALDH1A1GRM5MAOBMAPTMAOA | |
| SCHEMBL4423396 | 0.78 | ALDH1A1 (0.50) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL13673758 | 0.78 | KDM4E (0.60) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL4421919 | 0.76 | ALDH1A1 (0.58) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL4423371 | 0.76 | ALDH1A1 (0.51) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL4429412 | 0.75 | GRM5 (0.59) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL4426644 | 0.73 | SMN1; SMN2 (0.58) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL4424040 | 0.72 | ALDH1A1 (1.00) | TSHRKDM4EALDH1A1NPSR1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7598384-B2 | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-10-06 | — | — | US | disclosed |
| US-7598384-B2 | Tetrahydroquinolinones and their use as antagonists of metabotropic glutamate receptors | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-10-06 | — | — | US | disclosed |
| EP-1723116-B1 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO KGAA (DE) | 2008-09-24 | — | — | EP | disclosed |
| WO-2005082856-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-09 | — | — | WO | disclosed |