Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BUB1 | O43683 | 3/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422412 | 0.78 | ALDH1A1 (0.49) | RXFP1TP53THRBALDH1A1HSD17B10 | |
| SCHEMBL370336 | 0.75 | TDP1 (0.46) | RXFP1TP53THRBALDH1A1HTT | |
| SCHEMBL17372395 | 0.73 | RXFP1 (0.50) | RXFP1TP53THRBALDH1A1HTT | |
| SCHEMBL2468516 | 0.71 | RXFP1 (0.42) | RXFP1TP53THRBALDH1A1HTT | |
| SCHEMBL7661207 | 0.71 | RXFP1 (0.42) | RXFP1TP53THRBALDH1A1HTT | |
| SCHEMBL4325559 | 0.68 | CYP2C19 (0.45) | RXFP1TP53THRBALDH1A1HTT | |
| SCHEMBL7671814 | 0.68 | RXFP1 (0.40) | RXFP1TP53THRBALDH1A1HTT | |
| SCHEMBL7670474 | 0.67 | RXFP1 (0.39) | RXFP1TP53THRBALDH1A1HTT | |
| SCHEMBL17371875 | 0.66 | CDC7 (0.65) | RXFP1MAPK1BUB1 | |
| SCHEMBL21637792 | 0.63 | RXFP1 (0.59) | RXFP1TP53THRBALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005082856-A2 | TETRAHYDROQUINOLINONES AND THEIR USE AS ANTAGONISTS OF METABOTROPIC GLUTAMATE RECEPTORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2005-09-09 | — | — | WO | disclosed |