Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.42 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8355480 | 0.81 | ELANE (0.49) | NPC1RAB9ASMN1; SMN2SIGMAR1AGTR2 | |
| SCHEMBL8281753 | 0.81 | ELANE (0.49) | NPC1RAB9ASMN1; SMN2SIGMAR1AGTR2 | |
| SCHEMBL6358373 | 0.77 | PREP (0.57) | MEN1KMT2ANPSR1PREPNPC1 | |
| SCHEMBL6105877 | 0.77 | PREP (0.57) | MEN1KMT2ANPSR1PREPNPC1 | |
| SCHEMBL16256991 | 0.76 | MEN1 (0.49) | MEN1KMT2ANPSR1PREPNPC1 | |
| SCHEMBL14546519 | 0.76 | AGTR2 (0.46) | NPC1RAB9ASMN1; SMN2SIGMAR1AGTR2 | |
| SCHEMBL8279476 | 0.76 | ELANE (0.44) | NPC1RAB9ASMN1; SMN2AGTR2FKBP1A | |
| SCHEMBL10137614 | 0.76 | ELANE (0.44) | NPC1RAB9ASMN1; SMN2AGTR2FKBP1A | |
| SCHEMBL8280446 | 0.76 | AGTR2 (0.46) | NPC1RAB9ASMN1; SMN2SIGMAR1AGTR2 | |
| SCHEMBL14569818 | 0.76 | AGTR2 (0.46) | NPC1RAB9ASMN1; SMN2SIGMAR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730142-B1 | NOVEL KETOAMIDES WITH CYCLIC P4'S AS INHIBITORS OF NS3 SERINE PROTEASE OF HEPATITIS C VIRUS | SCHERING CORP (US) | 2011-06-29 | — | — | EP | disclosed |
| WO-2005085197-A1 | CYCLOBUTENEDIONE GROUPS-CONTAINING COMPOUNDS AS INHIBITORS OF HEPATITIS C VIRUS NS3 SERINE PROTEASE | SCHERING CORPORATION (US) | 2005-09-15 | — | — | WO | disclosed |