Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.36 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TNF | P01375 | 2/20 | 0.33 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.33 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | GFER | P55789 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8284602 | 0.88 | KDM4E (0.38) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL12226841 | 0.87 | KDM4E (0.34) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL8284695 | 0.81 | KDM4E (0.46) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL8241914 | 0.80 | SOS1 (0.43) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL8284699 | 0.79 | ALDH1A1 (0.40) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL8284674 | 0.79 | SOS1 (0.42) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL8284698 | 0.79 | CDK1 (0.42) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL8284672 | 0.77 | SOS1 (0.41) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL8249749 | 0.76 | KDM4E (0.39) | KDM4EHPGDUSP2HSD17B10ALDH1A1 | |
| SCHEMBL8284612 | 0.75 | PPARG (0.42) | KDM4EHPGDUSP2HSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1697343-B1 | AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARM LTD (IE) | 2009-07-01 | — | — | EP | disclosed |
| WO-2005058869-A1 | AMINOBENZIMIDAZOLES AND BENZIMIDAZOLES AS INHIBITORS OF RESPIRATORY SYNCYTIAL VIRUS REPLICATION | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-06-30 | — | — | WO | disclosed |