Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.54 |
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5871831 | 0.91 | PDE11A (0.57) | PDE11ABRD4JAK2KMT2APIK3CB | |
| SCHEMBL8285164 | 0.89 | PDE11A (0.55) | PDE11ACNR1CNR2KMT2APIK3CB | |
| SCHEMBL8286050 | 0.88 | PDE11A (0.54) | PDE11AKMT2AMAPT | |
| SCHEMBL8286344 | 0.88 | PDE11A (0.64) | PDE11AKMT2APIK3CBPIK3CDPIK3CA | |
| SCHEMBL8285166 | 0.87 | PDE11A (0.60) | PDE11AKMT2APIK3CBPIK3CDPIK3CA | |
| SCHEMBL8285176 | 0.86 | PDE11A (0.52) | PDE11AKMT2AMAPT | |
| SCHEMBL8286346 | 0.86 | PDE11A (0.61) | PDE11AKMT2APIK3CBPIK3CDPIK3CA | |
| SCHEMBL8286342 | 0.85 | PDE11A (0.60) | PDE11AKMT2APIK3CBPIK3CDPIK3CA | |
| SCHEMBL5871598 | 0.83 | PDE11A (0.58) | PDE11AKMT2APIK3CBPIK3CDPIK3CA | |
| SCHEMBL5872109 | 0.83 | PDE11A (0.75) | PDE11APIK3CBPIK3CDPIK3CAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |