Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 4/20 | 0.34 |
| ▸ | CCND1 | P24385 | 4/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | CCND2 | P30279 | 2/20 | 0.34 |
| ▸ | CCND3 | P30281 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8285171 | 0.99 | PDE11A (0.44) | PDE11AALDH1A1TSHRHTTKMT2A | |
| SCHEMBL8287407 | 0.85 | PDE11A (0.43) | PDE11AALDH1A1HPGDKDM4ECNR2 | |
| SCHEMBL5872175 | 0.85 | PDE11A (0.47) | PDE11AALDH1A1TSHRHTTHPGD | |
| SCHEMBL8286397 | 0.85 | KDM4E (0.49) | PDE11AHTTHPGDKDM4EHSD17B10 | |
| SCHEMBL5871541 | 0.84 | PDE11A (0.46) | PDE11AALDH1A1TSHRHTTHPGD | |
| SCHEMBL8287393 | 0.83 | PDE11A (0.46) | PDE11AALDH1A1HTTHPGDKDM4E | |
| SCHEMBL8287397 | 0.83 | PDE11A (0.46) | PDE11AALDH1A1HTTCYP1A2HPGD | |
| SCHEMBL8358812 | 0.82 | PDE11A (0.46) | PDE11AALDH1A1HPGDPOLBGAA | |
| SCHEMBL8285169 | 0.82 | PDE11A (0.45) | PDE11AALDH1A1HTTKMT2AHPGD | |
| SCHEMBL8285223 | 0.81 | PDE11A (0.44) | PDE11AALDH1A1HTTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005091857-A2 | 1,6-NAPHTHYRIDINE AND 1,8-NAPHTHYRIDINE DERIVATIVES AND THEIR USE TO TREAT DIABETES AND RELATED DISORDERS | BAYER PHARMACEUTICALS CORPORATION (US) | 2005-10-06 | — | — | WO | disclosed |
| WO-2003027112-A1 | 1, 8-NAPHTHYRIDINE DERIVATIVES AS ANTIDIABETICS | BAYER PHARMACEUTICALS CORPORATION (US) | 2003-04-03 | — | — | WO | disclosed |